Ophthalmic gene therapy company Ikarovec launches with £2.5m seed funding

Founded by UKI2S with co-investment from LifeArc & Parkwalk to advance a diabetic macular edema gene therapy and other pipeline products

Ikarovec, which is developing novel gene therapies to treat major ophthalmic indications, has launched today with £2.5m of seed funding from leading UK start-up investors UKI2S, LifeArc and Parkwalk. Primary use of funds is to take the company’s lead programme, a multicistronic gene therapy for diabetic macular edema (DME), to IND-enabling studies. Ikarovec was founded in 2019 by Chief Scientific Officer Dr Peter Widdowson, around intellectual property spun out of Quethera, which he founded and was bought by Astellas in 2018.

The proceeds of the fundraising will also be used to develop the company’s three earlier stage novel gene therapy products for major ophthalmic indications, build the intellectual property portfolio and establish its own laboratories. The lead programme is the first gene therapy for impaired visual acuity associated with DME, designed to manufacture three therapeutic proteins in the retina to target leaking vessels and inflammation. This ‘polypharmacy’ gene therapy will be delivered by a novel exosome-based system. Encouraging data has been generated in in vitro cell assays.  DME is the leading cause of blindness in the working age population.

Dr Robert Haigh is Executive Chairman of Ikarovec, bringing extensive business development and ophthalmic expertise via roles at Boehringer Ingelheim, Ferring and KalVista. In association with the fundraising, he is joined on the Board by Oliver Sexton, Investment Director at UKI2S, David Holbrook, Head of the Seed Fund at LifeArc, and Dr Cassie Doherty, Investment Director at Parkwalk.

Robert Haigh, Executive Chairman of Ikarovec, said, ‘The increasing incidence of debilitating ophthalmic diseases brings morbidity and economic cost, and we are pleased to announce our seed funding today to tackle these urgent issues. We thank our investors UKI2S, LifeArc and Parkwalk for their support, and look forward to working with them to build Ikarovec into a leading gene therapy company.’

Oliver Sexton of UKI2S said, ‘Ikarovec’s innovative approach offers a potential one-shot treatment for hugely debilitating and common eye disorders. The multi-gene approach has already shown success and UKI2S is excited to be working with such a strong team to develop cutting edge therapies.’

Dr David Holbrook, Head of LifeArc’s Seed Fund commented: ‘Our Seed Fund is focused on investing in companies with a promising scientific concept and by applying our translational expertise we hope to develop these into new interventions that address patient need. We are delighted to be backing Ikarovec and its team with great experience in ocular medicine, in particular ocular gene therapy. We look forward to working with our co-investors in helping the team succeed in bringing vital new therapies to patients.’

Cassie Doherty, Investment Director, Parkwalk, said, ‘We are very happy to be supporting the team at Ikarovec, where CSO Peter Widdowson and Executive Chairman Robert Haigh bring a wealth of technical, commercial, entrepreneurial knowledge and expertise to the company. Ikarovec’s multi-targeted approach has great potential to help close the gap of unmet clinical need, which will ultimately improve patient outcomes.’